clofibrate CAS#:637-07-0_上海皓元生物医药科技有限公司

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clofibrate

CAS号	637-07-0
规格	1g5g	纯度	98%
货号	HY-B0287	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	1g5g
纯度	98%
货号	HY-B0287
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥500.00 元/1g

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货号	品牌	纯度	规格	参考价	货期
HY-B0287	Medchemexpress	98%	1g5g	￥500.00元/1g	3天

产品详情

详细信息(中文)：
Clofibrate (Atromid-S)能增加PPARα的表达和活性，可用于III型高脂血症。

详细信息(英文)：
产品描述：ClofibrateClofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia._x000D_ Target: PPAR alpha_x000D_ Clofibrate treatment significantly increased PPARα protein expression and PPARα activity in SHR rats, but not in WKY rats. Moreover, the vasoconstrictor response of aortic ring was markedly increased in SHRs, which was blunted after clofibrate treatment.Conclusion:PPARα contributes to regulation of blood pressure and vascular reactivity in SHR, and clofibrate-mediated reduction in blood pressure and proteinuria is probably through increased NO production [1]. The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering (47% more deaths during treatment with clofibrate and 5% after treatment with clofibrate) than the non-treated high cholesterol group. The 公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商，产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。 MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利； MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；数千种产品在上海有充足备货，24-48小时内送达客户；大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。产品链接：www.medchemexpress.cn/clofibrate.html