欢迎来到化学加!萃聚英才,共享化学!化学加,加您更精彩!客服热线:400-8383-509

化学加_合成化学产业资源聚合服务平台

020-29116152

(工作日8:30-18:00)

图片加载中
LOADING IMAGES
2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide

2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide

CAS号 1403764-72-6
规格 10mg50mg
纯度 98%
货号 HY-16586
货期 3天
品牌 Medchemexpress
库存 ---
注意:请务必与卖家联系核实单价库存,以确保您的资金安全及交易顺利。
参考价: ¥1450.00 元/10mg
货号 品牌 纯度 规格 参考价 货期
HY-16586 Medchemexpress 98% 10mg50mg ¥1450.00元/10mg 3天

产品详情

详细信息(中文):
PFI-1能阻断BET BRDs与H3、H4乙酰化组蛋白尾巴的相互作用。
详细信息(英文):
产品描述:PFI-1PFI-1 can efficiently block the interaction of BET BRDs with H3 and H4 acetylated histone tails. _x000D_ IC50 Value: 1.89 nM (EC50 for the inhibition of IL6 production from human blood mononuclear cells stimulated by LPS)_x000D_ Target: BET BRDs_x000D_ Inhibition of the BET-histone interaction results in transcriptional downregulation of a number of oncogenes, providing a novel pharmacologic strategy for the treatment of cancer._x000D_ in vitro: Exposure of sensitive cell lines with PFI-1 results in G1 cell-cycle arrest, downregulation of MYC expression, as well as induction of apoptosis and induces differentiation of primary leukemic blasts. Intriguingly, cells exposed to PFI-1 showed significant downregulation of Aurora B kinase, thus attenuating phosphorylation of the Aurora substrate H3S10 [1], The compound showed

产品百科查看更多

英文名 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide
中文名 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide
CAS号 1403764-72-6 溶解性 ---
分子量 347.38900 熔点 ---
密度 --- 沸点 ---

商家信息

上海皓元生物医药科技有限公司

营业执照已审核 企业已认证

联系人:皓元 点击这里给我发消息

号码一: 400****

号码二: 021****

VIP企业默认展示联系方式,非VIP企业仅限注册登录用户可见

  • 公司类型:研发型
  • 成立时间:2009-03-17
  • 所在地区:上海市市辖区
  • 注册资本:300万元
推荐供应商

产品:2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide