假尿苷 CAS#:1445-07-4_河北周酶生物科技有限公司

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假尿苷

CAS号	1445-07-4
规格	1KG/袋	纯度	99%
货号	ZM001	货期	需咨询
品牌	zhouzyme	库存	需咨询
规格	1KG/袋
纯度	99%
货号	ZM001
货期	---
品牌	zhouzyme
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥80.00 元/克

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货号	品牌	纯度	规格	参考价	货期
ZM001	zhouzyme	99%	1KG/袋	￥80.00元/克	---

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详细信息(中文)：
mRNA疫苗是将含有编码抗原蛋白的mRNA导入人体，直接进行翻译，形成相应的抗原蛋白，从而诱导机体产生特异性免疫应答，达到预防免疫的作用。
外源物质mRNA进入人体后，会激活人体的免疫系统，引发由mRNA本身引起的炎症反应，并可能导致mRNA还未发挥作用就被免疫系统清除。因此，引入天然修饰核苷酸是降低mRNA疫苗免疫原性的有效手段之一。
假尿苷（Pseudouridine）是RNA上最丰富的修饰核苷，又被称为RNA的“第五种核苷”。2005年，Katalin Karikó等人发现将假尿苷引入RNA中能降低其免疫原性，并且RNA的免疫原性随着假尿苷引入比例的增高而降低。2008年，Katalin Karikó等人又发现用假尿苷完全替代尿苷的mRNA不仅能极大地降低mRNA的免疫原性，还能提高mRNA的稳定性并增强其翻译能力。2015年，Oliwia Andries等人发现用N1-甲基假尿苷完全替代尿苷比用假尿苷完全替代尿苷更能降低mRNA的免疫原性，且更能增强mRNA的蛋白表达能力。
基于假尿苷、N1-甲基假尿苷的优秀表现，和市场供应受限的现状，河北周酶利用自身技术优势，潜心研发并顺利将假尿苷、N1-甲基假尿苷产业化，成功解决原料受限这一难题。若您对产品有兴趣，欢迎随时沟通。

详细信息(英文)：
mRNA vaccines introduce mRNA encoding antigenic proteins into the body, which undergo direct translation to form corresponding antigenic proteins, thereby inducing a specific immune response in the body to achieve the effect of preventive immunity.

Upon entry of exogenous mRNA into the body, it activates the immune system, triggering inflammatory reactions caused by the mRNA itself, and may lead to clearance of the mRNA before it can exert its effect. Therefore, introducing naturally modified nucleotides is one of the effective means to reduce the immunogenicity of mRNA vaccines.

Pseudouridine is the most abundant modified nucleotide on RNA, also known as the "fifth nucleotide" of RNA. In 2005, Katalin Karikó and others discovered that introducing pseudouridine into RNA can reduce its immunogenicity, and the immunogenicity of RNA decreases with increasing proportions of pseudouridine. In 2008, Katalin Karikó and others found that using pseudouridine to completely replace uridine in mRNA not only greatly reduces the immunogenicity of mRNA but also enhances its stability and translation ability. In 2015, Oliwia Andries and others found that using N1-methyl pseudouridine to completely replace uridine can further reduce the immunogenicity of mRNA and enhance its protein expression ability compared to using pseudouridine alone.

Based on the excellent performance of pseudouridine and N1-methyl pseudouridine, as well as the limited market supply, Hebei Zhou Enzyme has utilized its own technological advantages to focus on research and development and successfully industrialized pseudouridine and N1-methyl pseudouridine, effectively solving the problem of limited raw materials. If you are interested in our products, please feel free to communicate with us at any time.

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物理化学性质
英文名	pseudouridine
中文名	假尿苷
CAS号	1445-07-4	溶解性	---
分子量	244.20100	熔点	---
密度	1.641g/cm3	沸点	598.4ºC at 760mmHg

商家信息

河北周酶生物科技有限公司

联系人：杨丽

号码一： 135****

号码二： ****

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公司类型：研发型
成立时间：2016-01-25
所在地区：河北省石家庄市
注册资本：500万元

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