Saxagliptin CAS#:361442-04-8_上海皓元生物医药科技有限公司

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Saxagliptin

CAS号	361442-04-8
规格	5mg10mg	纯度	98%
货号	HY-10285	货期	3天
品牌	Medchemexpress	库存	需咨询
规格	5mg10mg
纯度	98%
货号	HY-10285
货期	3天
品牌	Medchemexpress
库存	---
注意：请务必与卖家联系核实单价库存，以确保您的资金安全及交易顺利。
参考价：￥1200.00 元/5mg

立即询盘

货号	品牌	纯度	规格	参考价	货期
HY-10285	Medchemexpress	98%	5mg10mg	￥1200.00元/5mg	3天

产品详情

详细信息(中文)：
Saxagliptin(BMS477118)是选择性可逆的DPP4抑制剂，IC50和Ki分别为26 nM和1.3 nM。

详细信息(英文)：
产品描述：SaxagliptinSaxagliptin(BMS477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM._x000D_ IC50 value: 26 nM [1]_x000D_ Target: DPP4_x000D_ in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, Saxagliptin demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of saxagliptin is two-fold less potent than the parent. Both Saxagliptin and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases (selectivity of sitagliptin and vildagliptin for DPP4 is >2600 and